By Yuichi Yamamura, Ichiro Azuma (auth.), Thomas Klein, Steven Specter, Herman Friedman, Andor Szentivanyi (eds.)
The subject of organic reaction modifiers has attracted the eye of many biomedical investigators, together with immunologists, oncologists, pharmacologists, microbiologists, and biochemists, in addition to scientific practitioners of drugs. This has happened often as a result of attention that the complicated method of mobile and humoral interactions culminating in a effective immune reaction is below beautiful regulatory regulate for regular immune responses and that lack of keep an eye on could markedly impression the aptitude of a number to reply in a efficient demeanour to the various immunologic "insults" encountered within the surroundings. moreover, organic reaction amendment is taken into account by means of many to be a average offshoot of the really new software of "immunotherapy" to melanoma. it truly is well known that "immunotherapy" was once practiced on the finish of the final century and the start of this century whilst it used to be well-known that microbial infections have been because of specific species of micro organism and that passive management of serum con taining antibody to those microbes or their items may possibly, in lots of instances, favorably impression the end result of an infectious process.
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Lymphotoxin (LT) Induction of IF Activity in Human PBL Cu1tures 1 IF (units/m1) Hours of Incubation Treatment Control 15 hrs. 24 hrs. 48 hrs 72 hrs. 9 9 7 7 512 units/ml LT 1083 1833 3667 8000 1024 units/m1 LT 1750 3167 3667 3500 1 Human PBL were cultured in the presence and absence of cell-line derived LT. Supernatants were harvested at indicated timepoints and assayed for IF activity. Both doses of LT resulted in significant increases in IF titer of the culture supernatants. C. H. ROBBINS 40 supernatants 72 hours after culture initiation.
First, can the direct actions of IFNs be exerted in the system if the cytotoxic agent has affected the target cells? We know from in vitro studies that cells treated with cytotoxic substances fail to respond fully to IFN's antiviral action (13). On the other hand, in vitro studies suggest that the cytostatic activity of IFN might be enhanced in conjunction with other cytotoxic substances (14). It is, therefore, difficult to predict what to expect with combined therapy in terms of the direct actions of IFNs.
C1in. Use of Interferons. Yugoslav. Acad. Sci. 1981. Personal communication. , 1900 Oak Terrace Lane, Thousand Oaks CA (USA) INTRODUCTION Recombinant DNA techniques have led to determination of the structure of human interferons and production of individual molecular species of interferon free from other species and other proteins simultaneously induced in human cell cultures. Comparison of the properties of different molecular species of interferon and molecular hybrids between the various species has indicated the extent to which the various biological properties of interferons may be separated.
Biological Response Modifiers in Human Oncology and Immunology by Yuichi Yamamura, Ichiro Azuma (auth.), Thomas Klein, Steven Specter, Herman Friedman, Andor Szentivanyi (eds.)