Blistering Diseases: Clinical Features, Pathogenesis, by Dédée F. Murrell PDF

By Dédée F. Murrell

ISBN-10: 3662456974

ISBN-13: 9783662456972

ISBN-10: 3662456982

ISBN-13: 9783662456989

This publication is a accomplished compendium of present wisdom on inherited and autoimmune blistering ailments that relates advances in our realizing of the pathogenetic mechanisms to administration of the person ailments. the purpose is to supply a close reference for dermatologists who deal with sufferers with those stipulations and an invaluable “one-stop details store” for experts outdoor of dermatology. The ebook opens by means of describing the constitution and biology of the skin and basement membrane quarter and discussing the genes and proteins which are goals for mutations and autoantibodies. The position of some of the diagnostic exams is defined, and medical manifestations of the explicit illnesses are offered by way of many top of the range illustrations. The different types of remedy applicable in particular stipulations are then defined intensive, with assurance of dressings, medicinal drugs, surgeries, gene treatment, and different novel methods. important algorithms are integrated either for checking out and tracking and for treatment.

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Additional info for Blistering Diseases: Clinical Features, Pathogenesis, Treatment

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1976;152(2): 72–86. 66. Seitz CS, Giudice GJ, Balding SD, Marinkovich MP, Khavari PA. BP180 gene delivery in junctional epidermolysis bullosa. Gene Ther. 1999;6(1):42–7. 67. Sonnenberg A, Calafat J, Janssen H, Daams H, van der Raaij-Helmer LM, Falcioni R, et al. Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion. J Cell Biol. 1991;113(4):907–17. 68. Carter WG, Kaur P, Gil SG, Gahr PJ, Wayner EA. Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes.

1995;155(11):5449–54. 58. Balding SD, Prost C, Diaz LA, Bernard P, Bedane C, Aberdam D, et al. Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain. J Invest Dermatol. 1996;106(1):141–6. 59. Hirako Y, Usukura J, Nishizawa Y, Owaribe K. Demonstration of the molecular shape of BP180, a 180kDa bullous pemphigoid antigen and its potential for trimer formation. J Biol Chem. 1996;271(23):13739–45. 60. Schumann H, Baetge J, Tasanen K, Wojnarowska F, Schacke H, Zillikens D, et al.

Stable nonviral genetic correction of inherited human skin disease. Nat Med. 2002;8(10):1166–70. Ortiz-Urda S, Lin Q, Green CL, Keene DR, Marinkovich MP, Khavari PA. Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue. J Clin Invest. 2003;111(2):251–5. McGrath JA, Mellerio JE. Epidermolysis bullosa. Br J Hosp Med (Lond). 2006;67(4):188–91. Brucker-Tuderman L, Mitsuhashi Y, Schnyder U. Anchoring fibrils and type VII collagen are absent from skin in severe recessive dystrophic epidermolysis bullosa.

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Blistering Diseases: Clinical Features, Pathogenesis, Treatment by Dédée F. Murrell


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